After graduating NYCDA in 1992, Fox made his debut on an episode of Wings. Still not a familiar face on the small screen, he continued getting cast in supporting roles, including the role of Charlie in the CBS Schoolbreak Special series, If I Die Before I Wake before he made his big screen debut in My Boyfriend's Back (1993). In 1994, Fox was cast in a co-starring role as the eldest of five siblings who lose both parents in a car accident on the 1990s Party of Five, as Charlie Salinger. In 1996, People Magazine named Fox one of the 50 Most Beautiful People in the World. After Party of Five was canceled following its sixth season, Fox starred in another TV series, Haunted, in 2002. From September 2004 until May 2010, Fox played the role of the dedicated yet troubled surgeon, Dr. Jack Shephard, on Lost. Fox was nominated for a Golden Globe, won the 2005 Satellite Award, and shared the 2006 Screen Actors Guild Award for “Outstanding Performance by an Ensemble in a Drama Series”, for his role in Lost. On December 2, 2006, he hosted Saturday Night Live with musical guests Tenacious D. In 2006, Fox co-starred with Matthew McConaughey in the sports drama, We Are Marshall. He also played a bit part in the action film Smokin' Aces and starred in the 2008 thriller, Vantage Point. In May 2008, Fox starred as Racer X in the movie Speed Racer.